Clinical Chemistry - Cholinesterase

The Randox Cholinesterase (butyryl) reagent is used for the quantitative in vitro determination of BCHE in serum and plasma. BCHE can be used to diagnose cholinesterase (butyryl) deficiency and curariform drugs toxicity.

The Randox Cholinesterase (butyryl) reagent can also be used as a diagnostic and therapeutic marker for Alzheimer’s disease as BCHE activity progressively increases in patients with Alzheimer’s disease whereas acetylcholinesterase activity remains the same or declines. In Alzheimer’s disease, BCHE is found in association with beta-amyloid plaques and the cerebral cortex, whereas it is not commonly found in any other case. A study carried out by NCBI found that when the BCHE gene is not found in the brain, there are up to 70% less beta-amyloid plaques.