Specific Proteins - Haptoglobin

Haptoglobin measurements are used in the diagnosis of haemolytic anaemia and to distinguish it from other types of anaemia. In haemolytic anaemia, haptoglobin levels in the blood decrease significantly. Low levels however may also indicate red blood cell destruction due to sickle cell anaemia or thalassemia. In certain cases of liver disease haptoglobin levels may also be low, as the liver cannot manufacture normal levels of the protein.

As an acute phase reactant haptoglobin levels in the blood are significantly increased in response to infection, inflammation, burns, surgery and trauma. However, haptoglobin is not generally used to diagnose or monitor these conditions.