Diabetes - Beta-2 Microglobulin

levated concentration levels of beta-2 microglobulin is attributed to diseases with a high cell turnover. It is a powerful prognosis factor for multiple myeloma, a type of bone marrow cancer. It is also used to detect chronic lymphocytic leukemia and some types of lymphomas.

Low concentration levels of beta-2 microglobulin in serum and high concentration levels is urine is attributed to renal tubular disease. This is particularly important during the onset on diabetes as the kidneys grow larger and the glomerular filtration rate (GFR) becomes supranormal which are risk factors for the development of diabetic nephropathy in later life.